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Studies find clear association between fitness and mental health

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New research from a large study demonstrates that low cardiorespiratory fitness and muscle strength have a significant association with worse mental health.

Researchers have reported a clear link between low physical fitness and the risk of experiencing symptoms of depression, anxiety, or both.

The study, which included more than 150,000 participants, found that cardiorespiratory fitness and muscle strength independently contribute to a greater risk of worse mental health.

However, the researchers saw the most significant association when they looked at cardiorespiratory fitness and muscle strength in combination. This research may help inform clinical guidance on mental health and physical fitness.

Physical and Mental Health

Problems with mental health, just like physical health issues, can have a significant negative effect on a person’s life. Two of the more common mental health conditions are anxiety and depression.

According to the Anxiety and Depression Association of America, 18.1% of adults in the United States have experienced an anxiety disorder in the past year. In addition, the National Institute of Mental Health note that 7.1% of U.S. adults have had a major depressive episode.

There is growing evidence that being physically active may help prevent or treat mental health conditions. However, many questions still need answering.

The study is a robust prospective study with a long follow-up period of 7 years and objective measures of both the risk factor (cardiovascular fitness and muscle strength) and the outcome (depression, anxiety, or both).

Although it demonstrates a correlation between physical fitness and better mental health outcomes, this does not necessarily mean that there is a causal relationship between the two. For example, it could be that people with better mental health are more likely to stay physically active.

However, the researchers deployed various statistical techniques that they say suggest that there is likely to be a causal relationship between physical fitness and better mental health.

In addition to adjusting for potential confounding factors that are associated with both low levels of fitness and depression and anxiety — such as smoking — the authors also conducted a number of sensitivity analyses.

They checked for reverse causation (when the outcome is actually the cause) by excluding people who were depressed or anxious at the start of the study. They also changed the cut-off values that determined whether people had depression. Neither of these analyses changed their findings.

What remains is the need to demonstrate the mechanisms that might account for this relationship.

Nonetheless, the findings are still important. As well as providing further evidence for the beneficial effects of physical activity on mental health, the study is also one of the first to use objective measures of physical fitness to do so.

For the researchers, this could mean that quantitative physical fitness measures and, in particular, measures of both cardiorespiratory fitness and muscle strength — rather than self-reports of physical activity — could potentially serve as indicators of mental health risk for clinicians.

Encouragingly, the researchers note that a person can meaningfully improve their physical fitness in as little as 3 weeks. Based on their figures, this may reduce the person’s risk of developing a common mental health condition by up to 32.5%.

For Kandola, the findings are particularly pertinent given the effects of the current COVID-19 pandemic.

“Reports that people are not as active as they used to be are worrying, and even more so now that global lockdowns have closed gyms and limited how much time people are spending out of the house,” says Kandola. “Physical activity is an important part of our lives and can play a key role in preventing mental health disorders.”

Drug to reduce bleeding could treat COVID-19

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A recent study has shown that aprotinin, a drug that reduces the risk of bleeding during surgery, can stop the novel coronavirus from entering host cells. The drug could serve to prevent severe cases of COVID-19, the authors say.

A new study that researchers at Goethe University Frankfurt, Germany, led has shown that the anti-bleeding drug aprotinin (Trasylol) can stop SARS-CoV-2 from entering host cells. The authors say that aprotinin could prevent COVID-19 from progressing to a severe, systemic disease.

The protease step

Aprotinin is an inhibitor of fibrinolysis, the process leading to the breakdown of blood clots. Doctors sometimes use it during surgery to reduce the risk of bleeding and, consequently, the need for blood transfusions.

Aprotinin is also a protease inhibitor, which is important in the context of COVID-19.

This is because cleavage of the coronavirus spike protein — which a protease performs — is an essential step in the viral life cycle, allowing the virus access to cells in the body. This cleavage must take place for the virus to be able to bind to its receptors on the surface of our cells.

To investigate whether aprotinin could prevent this critical step, and thereby stop the virus from entering cells, the team behind this study performed various experiments

Cell culture experiments

The researchers added aprotinin to cells both before and after they infected them with the virus. The results showed that aprotinin effectively prevented the virus from entering the cells (and, therefore, from replicating) in both cases.

The testing process involved various cell types, including cells isolated from the surface of human bronchi, and a range of concentrations of aprotinin. The team also tested the drug against three different strains of the virus outside of cells.

Importantly, the results showed that aprotinin was effective in inhibiting the virus at levels that doctors could realistically give to a patient (i.e., at therapeutic doses).

“Our findings show that aprotinin is effective against SARS-CoV-2 in concentrations that can be achieved in patients,” comments senior author Prof. Jindrich Cinatl, a professor at the Institute for Medical Virology at the University Hospital Frankfurt

Therapeutic precedent

If aprotinin gets approval for use as a COVID-19 treatment, doctors could use it to prevent severe cases of the disease from developing by suppressing levels of the virus and preventing lung injury.

The team is hopeful that it would be possible to roll aprotinin out to the patient population relatively quickly, as it is already approved for similar uses. The drug could potentially also treat respiratory infections with similar viruses.

In Russia, an aerosol form of aprotinin has received approval for the treatment of flu, which shares similarities with COVID-19. Influenza viruses use proteases to gain entry to host cells in a similar way to SARS-CoV-2.

However, scientists must carefully consider the side effects, particularly in relation to blood clots, before giving the drug to patients. It is not yet clear whether aprotinin would reduce or promote blood clotting in people with COVID-19.

Kano Hisbah board bars radio station from using the term ‘Black Friday’

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The Kano State Hisbah Board, which is tasked with the duty of enforcing Sharia law in Kano State, has written a letter to a radio station, in Kano State, 96.9 Cool FM, for using the term ‘Black Friday’.

Black Friday is an informal name for the Friday following Thanksgiving Day in the United States, which is celebrated on the fourth Thursday of November. The term is used worldwide to mean a day for promotional sales where goods are sold at discounted prices.

However, in a letter signed by Principal Executive Officer II, Abubakar Ali, on behalf of the Commander-General, Hisbah stated that Friday is regarded as a holy day in Islam and tagging it as ‘black’ is derogatory and would not be condoned.

The letter titled, ‘Letter of Introduction’ reads in part, “I am directed to write and notify you that the office is in receipt of a complaint for the conduct of ‘Black Friday Sales’ on November 27, 2020.

“Accordingly, we wish to express our concern on the tagging of Friday as ‘Black Friday’ and further inform you that the majority of the inhabitants of Kano State are Muslims that consider Friday as a holy day.

“In view of the foregoing, you are requested to stop calling the day ‘Black Friday’ with immediate effect and note that the Hisbah Corps will be around for surveillance purposes with a view to avoiding occurrence of any immoral activities as well as maintaining peace, harmony and stability in the state.”

Hisbah, an Islamic police operating in many states in the North, has been accused of several human rights abuses.

It is known for accosting vehicles transporting alcoholic beverages and does not allow such vehicles to pass through the state. Hisbah’s Commander General, Sheik Aminu Daurawa, had said over 12 million bottles of beer were destroyed in 800 operations executed in seven years.

According to the National Broadcasting Commission Act, only NBC has the power to sanction a radio station especially in matters that relate to broadcasting.

No indicted rapist will go scot-free – Sanwo-Olu

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The Lagos State Governor, Babajide Sanwo-Olu, has said no offender indicted in reported cases of rape and gender-based violence will go scot-free under his watch.

The governor spoke on Thursday when he received a 54-page compendium on Sexual and Gender-Based Violence compiled by the Stakeholders’ Committee set up by this wife, Dr Ibijoke Sanwo-Olu, to give recommendations on how the fight against the crime can be won.

Sanwo-Olu, who is the incident commander for gender-based violence in Lagos, reiterated his administration’s commitment to protecting the vulnerable demographics and getting justice for victims violated.

The governor said, “I am delighted by the work done by the Stakeholders’ Committee to bring attention to the problems facing voiceless adults and children in our society. Through your efforts, vulnerable people are building the courage to speak out on offences of sexual violence and heal their wounds.

“We will bring people, who have been perpetrating these crimes, knowingly or unknowingly, to book. We will ensure they never walk freely without the full wrath of the law brought upon them. It is part of our responsibility to ensure that the vulnerable members of our society have a voice and have access to where they can get justice when their rights are violated.”

Earlier, Ibijoke had called on the government to step up the response geared towards reducing sexual and gender-based violence to the barest minimum.

She said her drive was to work with the committee and create a society where gender-based violence would be reduced to barest minimum.

She said, “The stakeholders have been having meetings for months and their discussions have focused on the key development pillars of the current administration as they relate to the rights of vulnerable citizens, especially those women and children.

“The Office of the First Lady has been working with the vision to reduce sexual and gender-based violence to the barest minimum if it is impossible to eradicate the crime. We have activated our response, bringing all stakeholders and communities on board to forge a common front in addressing the issue.”

Not being nominated for the Grammys doesn’t mean you’re not a great musician – Femi Kuti

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Nigeria’s Afro-beat legend, Femi Anikulapo-Kuti has said that not being nominated for the Grammys award does not mean a musician is not great.

Kuti said this while making reference to his father, Fela and Bob Marley who never got nominated or won Grammys award in his time.

The Afro-beat legend said Music is not about awards but spreading love and giving people will to go through hard times.

On his Twitter page, he wrote: “Music really isn’t about awards though. Fela never won or was never nominated. I don’t think Bob Marley was too.

“Music is about spreading love, giving people the will to go through the hard times in live, etc and inspiration. Music must bring comfort too.”

He, however, clarified that he is not referring to anyone in particular who got nominated for the Grammys, but himself who has been nominated four times for the award.

“This tweet on Grammys was concerning me saying I have four nominations. And all I’m saying is that it’s not the objective.

“Many GREAT musicians have never been nominated doesn’t mean they are not GREAT. I wasn’t referring to anyone but myself, some have chosen to abuse, or drag others. Pity.” He said.

Fashola should honourably resign or be sacked – Northern elders

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A member of the Northern Elders Forum and the Chairman of Maje Foundation, Alhaji Rufai Mukhtar Danmaje, has asked the Minister of Works, Babatunde Fashola to honourably resign his position for failing to complete any projects since his assumption of office as Works Minister five years ago.

Danmaje said it is no longer story that for example in the entire Northern region, no single project embarked upon by the Minister has been completed despite the huge tax payers money allocated to his ministry.

Mukhtar Danmaje who is presenting the views of the Northern Elders Forum, said if the Minister refused to voluntarily resign, the President Muhammadu Buhari should hesitate to quickly sack him and subject him to scrutiny to know what happens to Billions of Tax payers money allocated to his ministry.

“For example look at the issue of Mambila Hydro Power project. Over time the Minister has been deceiving the President and indeed Nigerians that works have reached high percentage but only for a committee to now expose that there is nothing on ground there”.

He noted that the issue of Mambila hydro Power project is enough to sack the minister or asking him to resign honorably, but he chooses to remain aloof as if all is alright.

He said, “if people like Fashola continue to talk about rotational Presidency back to the South, they might provoke us to reject voting for anybody from that region because we consider him a failure and nothing more.

“You could see that no single road project is been completed under Fashola in the entire Northern Nigeria even the darling Kano, Kaduna, Abuja road he is saying can’t be completed till after their tenure, so what are we saying?”

Talking about the problems of insecurity in the North, Danmaje worried that the region lacks leadership that will steer its mission and design a roadmap for its survival.

“We fall into the trap of insecurity for many reasons, one of which was because of lack of leadership in the region and indeed lack of tentative roadmap for its survival and indeed negligence of the traditional institution which earlier on were our mirrors.”

He always calls after big defeats – Mourinho speaks on relationship with late Maradona

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Jose Mourinho revealed the private side of Diego Maradona who would “call me after my big defeats, but never my victories” following the Argentina legend’s passing.

Maradona, one of the greatest players of all time, died at the age of 60 on Wednesday and Mourinho, who knew the World Cup winner well, paid tribute to his friend after Tottenham’s 4-0 win over Ludogorets in the Europa League 24 hours after he passed away.

“Maradona the world knows, the world never forgets,” he said. “I made sure that my son knows a lot about him, even being born after he was a player. I know my son will make sure when he is a father he will not let his kids forget.

“It was a bit similar with [Alfredo] Di Stefano; I never saw him play football, but my dad made sure I knew a lot about him. With these generations, we have players of our generations, and in my generation was what everybody knows.”

“Then there’s Diego the guy. That one, I miss. I feel sorry that I didn’t spend more time with him, I would have loved to. I think his family, his friends and colleagues are very privileged to know him well and spend time with him.

“I know him well enough and in my big defeats, he would always call me. In my big victories, never. But I will miss Diego, and I am very sad but I have a smile because with him, every minute I spent with him was to laugh.”

Sultan of Sokoto describes North as the worst place to be in Nigeria

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The Sultan of Sokoto, Sa’ad Abubakar, has described the North is the “worst place” to be in Nigeria owing to the region’s security challenges.

Speaking at a meeting of the Nigerian Inter-Religious Council on Thursday, Abubakar said something urgent must be done to address the situation before “we would lose sleep because of insecurity”.

A number of states across the north-west and north-central have been experiencing increasing attacks by suspected bandits and kidnappers.

The attackers have gone as far as kidnapping young girls — once abducting 26 — and also killing some of their hostages, including traditional rulers and politicians.

At the religious council’s meeting in Abuja, the Sultan said many attacks in the region are not reported, citing one a few weeks ago where “76 persons were killed in a community in Sokoto in a day”.

“Unfortunately, you don’t hear these stories in the media because it’s in the north. We have accepted the fact that the North does not  have strong media to report the atrocities of these bandits,” he said.

“People think north is safe but that assumption is not true. In fact, it’s the worst place to be in this country because bandits go around in the villages, households and markets with their AK-47 and nobody is challenging them.

“They stop at the market, buy things, pay and collect change, with their weapons openly displayed. These are facts, I know because I am at the centre of it.

“I am not only a traditional ruler, I am also a religious leader. So, I am in a better place to tell the story. I can speak for the north in this regard because I am fully aware of the security challenges there.

“We have to sincerely and seriously find solutions to the problem, otherwise, we will find ourselves soon, in a situation where we would lose sleep because of insecurity.”

I’ll leave the White House if electoral college formalizes Biden – Trump

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President Donald Trump said Thursday that he will leave the White House if the Electoral College formalizes President-Elect Joe Biden’s victory — even as he insisted such a decision would be a “mistake” — as he spent his Thanksgiving renewing baseless claims that “massive fraud” and crooked officials in battleground states caused his election defeat.

“Certainly I will. But you know that,” Trump said Thursday when asked whether he would vacate the building, allowing a peaceful transition of power in January. But Trump — taking questions for the first time since Election Day — insisted that “a lot of things” would happen between now and then that might alter the results.

 “This has a long way to go,” Trump said, even though he lost.

The fact that a sitting American president even had to address whether or not he would leave office after losing reelection underscores the extent to which Trump has smashed one convention after another over the last three weeks. While there is no evidence of the kind of widespread fraud Trump has been alleging, he and his legal team have nonetheless been working to cast doubt on the integrity of the election and trying to overturn voters’ will in an unprecedented breach of democratic norms.

Trump spoke to reporters in the White House’s ornate Diplomatic Reception Room after holding a teleconference with U.S. military leaders stationed across the globe. He thanked them for their service and jokingly warned them not to eat too much turkey, then turned to the election after ending the call. He repeated grievances and angrily denounced officials in Georgia and Pennsylvania, two key swing states that helped give Biden the win.

Trump claimed, despite the results, that this may not be his last Thanksgiving at the White House. And he insisted there had been “massive fraud,” even though state officials and international observers have said no evidence of that exists and Trump’s campaign has repeatedly failed in court.

Trump’s administration has already given the green light for a formal transition to get underway. But Trump took issue with Biden moving forward.

“I think it’s not right that he’s trying to pick a Cabinet,” Trump said, even though officials from both teams are already working together to get Biden’s team up to speed.

See Also: Trump appears to admit election defeat as he finally lets Biden begin presidential transition

And as he refused to concede, Trump announced that he will be traveling to Georgia to rally supporters ahead of two Senate runoff elections that will determine which party controls the Senate. Trump said the rally for Republican Sens. David Perdue and Kelly Loeffler would likely be held Saturday. The White House later clarified he had meant Dec. 5.

One of the reasons Republicans have stood by Trump and his baseless claims of fraud has been to keep his loyal base energized ahead of those runoffs on Jan. 5. But Trump, in his remarks, openly questioned whether that election would be fair in a move that could dampen Republican turnout.

“I think you’re dealing with a very fraudulent system. I’m very worried about that,” he said. “People are very disappointed that we were robbed.”

As for the Electoral College, Trump made clear that he will likely never formally concede, even if he said he would leave the White House.

“It’s gonna be a very hard thing to concede. Because we know there was massive fraud,” he said, noting that, “time isn’t on our side.”

“If they do,” vote against him, Trump added, “they’ve made a mistake.”

Asked whether he would attend Biden’s inauguration, Trump said he knew the answer but didn’t want to share it yet.

But there were some signs that Trump was coming to terms with his loss.

At one point he urged reporters not to allow Biden the credit for pending coronavirus vaccines. “Don’t let him take credit for the vaccines because the vaccines were me and I pushed people harder than they’ve ever been pushed before,” he said.

As for whether or not he plans to formally declare his candidacy to run again in 2024 — as he has discussed with aides — Trump said he didn’t “want to talk about 2024 yet.”

All states must certify their results before the Electoral College meets on Dec. 14, and any challenge to the results must be resolved by Dec. 8. States have already begun that process, including Michigan, where Trump and his allies tried and failed to delay the process, and Georgia and Pennsylvania.

Vote certification at the local and state level is typically a ministerial task that gets little notice, but that changed this year with Trump’s refusal to concede and his unprecedented attempts to overturn the results of the election through a fusillade of legal challenges and attempts to manipulate the certification process in battleground states he lost.

Biden won by wide margins in both the Electoral College and popular vote, where he received nearly 80 million votes, a record.

Lai denies announcing N5m hate speech fine despite video evidence

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The minister of information, Lai Mohammed, has denied announcing the increment of hate speech fine from N500,000 to N5 million.

The minister’s position was contained in a counter-affidavit in response to a suit filed against him at a federal high court in Lagos.

In August, the minister unveiled the amendment to the country’s broadcasting code in Lagos where the increment of the new fine was announced.

Inibehe Effiong, human rights lawyer, is currently challenging the fine by the National Broadcasting Commission (NBC) on Nigeria Info FM.

The radio station was fined for alleged hate speech. Obadiah Mailafia, former deputy governor of the Central Bank of Nigeria (CBN), had alleged that a northern governor is one of the leaders of Boko Haram.

However, in the affidavit deposed by Sunday Ojobo, an official of the Information ministry, the minister said he never announced the increase of the hate speech fine.

“Paragraph 19 is denied. The 2nd defendant (Mohammed) did not announce an increment in any fine for hate speech from N500,000 to N5,000,000 or any other because there is a governmental body or institution mandated to regulate and enforce the Nigerian Broadcasting Code,” Ojobo said in the affidavit.

“The constitution of the federal republic of Nigeria provides for derogation from fundamental rights in the interest of public safety, public order and for the purpose of protecting the rights and freedom of other persons.

“The first respondent (NBC) has powers in determining and applying sanctions including revocation of licences of defaulting stations which do not operate in accordance with the broadcast code and in the public interest.

“A public affairs commentator, anchor of programmes and the media are not to use their platform to incite public violence or disorder or in a manner detrimental to the national interest.

“It is within the purview of the federal government of Nigeria to maintain public safety, public order in the interest of all citizens of Nigeria to avoid breakdown of law and order.”

On its part, the broadcasting commission said it has the right to sanction any media outfit that does not conform to the broadcasting code.